Bryan Mbeumo scored twice as Brentford beat woeful Southampton for the first time. first division away victory of the season.
The Cameroonian striker, linked with a possible move to Arsenal in January, piled on the misery for Saints, who were bottom after Kevin Schade had put the Bees ahead.
Keane Lewis-Potter and Yoane Wissa added insult to injury in injury time at the end of another utterly miserable afternoon for Southampton.
The new technical rebound they were looking for replacing Russell Martin with Ivan Juric It has become more of a blow to the new coach after a third consecutive defeat since the Croatian was appointed.
They remain stuck on six points from 20 games and look not only doomed to relegation, but also in serious danger of breaking Derby's unwanted record of amassing just 11 points in an entire Premier League season.
Brentford had to wait just six minutes to take the lead when Mikkel Damsgaard stripped the ball from Joe Aribo and brilliantly tipped away Lesley Ugochukwu's challenge.
The Danish midfielder then slid a magnificent diagonal ball towards Schade, who calmly lofted it first time past Aaron Ramsdale and into the back of the net.
Brentford should have doubled their lead when Mbeumo ran forward and passed the ball through Jan Bednarek's legs to hit his teammate Wissa, but Ramsdale was quick to block his shot.
Moments later, Mathias Jensen's cross found Bees captain Christian Nørgaard, whose header hit the crossbar. The closest the toothless Saints came to tying was a Tyler Dibling shot that crashed into the side netting.
Early in the second half, Ramsdale saved Mads Roerslev at his near post before Taylor Harwood-Bellis somehow cleared Wissa's goal line.
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Brentford had the ball in the net after 50 minutes when Sepp van den Berg was left completely unmarked when he stooped to head in Mbeumo's corner, but a VAR check detected a push by Wissa on Bednarek.
Wissa should have put the game to bed on the hour when Schade beat him with a clever header, but attempting to throw Ramsdale almost cleared the stands behind the goal.
Instead, it fell to Mbeumo to finish for Saints, the striker playing in Wissa and running past his team-mate before smashing the ball back into the roof of the Ramsdale net.
Then, with 20 minutes remaining, Ugochukwu brought down Van den Berg as they battled for a Mbeumo cross, and the striker slotted the penalty beyond Ramsdale's dive.
In added time, Mbeumo set up Lewis-Potter to roll in the fourth, and Wissa took advantage of a defensive error to break through and score the fifth to deepen the darkness surrounding Southampton.
