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Brentford vs Sheffield Wednesday: Team news
Bees manager Thomas Frank has made five changes to the team that beat Ipswich Town 4-3 on Saturday.
One of those featured is former Liverpool star Fabio Carvalho, who has had a frustrating start to his life in west London.
Brentford XI: Flekken, Van den Berg, Collins, Mee, Meghoma, Janelt, Jensen, Carvalho, Lewis-Potter, Schade, Mbeumo.
Sheffield Wednesday XI: Charles, Lowe, Iorfa, Otegbayo, Johnson, Fusire, Paterson, Ingelsson, Musaba, Gassama, Ugbo.
On the other hand, Southampton manager Russell Martin cut and changed six players from the team that lost 1-0 to Manchester City.
Southampton XI: Ramsdale, Sugawara, Harwood-Bellis, Bednarek, Bree, Ugochukwu, Fernandes, Aribo, Fraser, Archer, Armstrong.
Substitutes: McCarthy, Taylor, Stephens, Wood, Amo-Ameyaw, Kamaldeen, Cornet, Brereton Diaz, Onuachu.
Stoke City XI: Johansson, Tchamadeu, Dixon, Rose, Phillips, Bocat, Thompson, Seko, Sidibe, Vidigal, Cannon.
Substitutes: Fielding, Anderson, Giani, Moran, Burger, Tezgel, Manhoef, Koumas, Ennis.