Mohamed Salah and Darwin Núñez have been left out of Liverpool's squad for the clash against Luton Town.
The Reds Presents the Hatters, live and exclusively. on talkSPORTas they look to move four points clear at the top of the Premier League table.
On the horizon is a Carabao Cup final date with Chelsea on Sunday and Reds boss Jurgen Klopp has made the decision to leave out two of his main attackers.
Salah will not include having returned from a hamstring injury before playing more than half in their 4-1 win at Brentford due to Diogo Jota's injury.
Nunez suffered an injury and was substituted at half-time, and Jurgen Klopp said the Uruguayan felt his muscle 'slightly'.
It is not yet clear whether Núñez will be available for the Wembley grand final.
Alisson continues to deal with a muscle injury, so Caoimhin Kelleher has returned to goal for Liverpool.
Joe Gomez has reappeared at left back, with Andy Robertson and Kostas Tsimikas named on the bench.
Klopp has also named plenty of youngsters on the bench, with 16-year-old Trey Nyoni in the first team for the first time.
Other stars such as Trent Alexander-Arnold, Jota and Dominik Szoboszlai remain out of the Reds in what has been a difficult week.
Injuries could affect their chances of winning the Carabao Cup, although Chelsea, who have had absences all season, will also miss key names.
Liverpool fans will be hoping to avoid any further injury setbacks with a trip to Wembley just days away.
Liverpool XI: Kelleher, Bradley, Quansah, Van Dijk, Gomez, Endo, Gravenberch, Mac Allister, Elliott, Diaz, Gakpo
Substitutes: Adrian, Konate, Tsmikas, Robertson, Clark, Gordon, McConnell, Danns, Nyoni