Liverpool suffered a major injury and Alisson will miss the clashes between Chelsea and Arsenal as the worrying return date is revealed.
Alisson is expected to miss around six weeks to give Liverpool a major blow ahead of their horror run, talkSPORT understands.
The 32-year-old man suffered a hamstring injury in Saturday's 1-0 away win at Crystal Palace.
He had just returned to action following a thigh problem in September, and is now set for an extended period on the sidelines.
The Brazilian was seen pounding the ground in anger when he was sent off in the second half at Selhurst Park.
Backup goalkeeper Caoimhin Kelleher will now replace Alisson between the sticks for the start of Liverpool's nightmare of matches.
Following the October international break, the Premier League leaders will face Chelsea and Arsenal immediately afterwards.
A Champions League clash at RB Leipzig, who can now count on former Reds coach Jurgen Klopp as advisoris sandwiched between those two decisive confrontations.
Liverpool They will then face Brighton in back-to-back matches, first at the Amex Stadum in the fourth round of the Carabao Cup, before welcoming them to Anfield in the top flight days later.
Then follows a highly successful meeting with Bayer Leverkusen in the European Cup, which will see the Liverpool legend. Xabi Alonso return to his old playground.
The difficult games don't end there, as Aston Villa will travel to Merseyside before the November international break.
Depending on how well Alisson recovers, he could return to play at Southampton on November 24, ahead of Liverpool's next series of horror games.
But if he suffers any setback during his rehabilitation, he could miss the match against Real Madrid on matchday four of the renewed Champions League.
Liverpool then kick off December with a mouth-watering game against Premier League champions Manchester City.
A midweek trip to Newcastle follows days later, with the Merseyside derby against Everton at Goodison Park taking place on December 7.
More to follow…