Manchester City couple Kyle Walker and Nathan Ake he will lose his last match before facing off Real Madrid on the 9th of April.
Head of the city Crystal Palace in Premier League action as the defending champions look to gain an advantage in the title race.
However, despite earlier optimism that Walker was fit in time to face Los Blancos, the situation remains uncertain.
Pep Guardiola indicated that both players would not make the trip to Selhurst Park with City fans particularly concerned about Walker's recovery.
The veteran defender played a vital role in the cancellation Vinicius Junior in his meeting last season and he will be in charge of the role again.
Both players are part of Guardiola's first line of defense, especially in European games, but the chances are that at least one of them will be missing in Madrid.
Guardiola is unlikely to risk a 19-year-old Rich Lewis as a man scorer on Vinicius Jr and John Stones he is set to start in a rotated defense.
